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Phase 2 trial data showed average weight loss of up to 24.2% at 48 weeks, while the newer Phase 3 trial data showed 28.7% average weight loss at 68 weeks on the 12mg dose

This in turn stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which mediates many of the anabolic and metabolic effects associated with human growth hormone

Following a week of acclimatization, all the rats ( n = 50) were randomly assigned into NF, HF, HF + Met, HF + L-car, and HF + met + L-car groups ( n = 10 per group)

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